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Monday, December 1, 2014

Stem Cell Banking of Menstrual Blood Cells

Stem cells in the menstrual blood are extremely proliferation and hold a unique capability of developing into a variety of healthy cells. These valuable stem cells are discarded during a woman’s menstrual cycle. It is a lesser known fact that the stem cells in menstrual blood have similar regenerative ability like the stem cells in umbilical cord blood and bone marrow. Women in their reproductive years can preserve these cells for future use for her or possibly a family member in need.

Using a medical-grade silicone cup in place of a tampon or sanitary napkin, the menstrual blood is collected in a physician’s office. For safety measures during storage, the menstrual stem cells are collected from a single sample and processed, purified, harvested, amplified and correctly stored. The over wrapped vials are cryogenically preserved in a facility that is closely supervised round the clock to make sure that your menstrual stem cells are safe and ready for future use. Over the years, these cells have been utilized widely for various cosmetic procedures.

Each month during a woman’s menstrual period, the uterine lining – Endometrium is shed along with the surplus blood and tissues. This lining of the uterus possesses a huge number of mesenchymal stem cells and numerous thousand fold high concentration of stem cell growth factors. These cells from the endometrium are distinctive and unique because they have several properties and characteristics similar to bone marrow and embryonic stem cells. The aim of mesenchymal cell therapy is to treat diseases of non-hematopoietic tissues in an analogous fashion to treating leukemia with hematopoietic stem cell transplantation. Menstrual stem cells possess the potential to differentiate into possibly every other cell type in the human body making them very useful to treat future diseases.

Banking your cells at a renowned stem cell bank that offers women with an extensive opportunity to build their own healthcare portfolio will also help in preserving it for a long run and making it readily available for future use. Considering the relevance and importance in treatment of rare and chronic diseases that include certain neuro disorders, it has become crucial for women to preserve their menstrual blood in the menstrual blood bank.

Wednesday, November 12, 2014

Egg Donation Process

Giving birth can be one of the most beautiful experiences for a woman. Although rife with challenges, health issues and various other grave considerations, childbirth is something that almost every woman looks forward to, some time or the other, in her life. Sadly, however, not all women are equally endowed in this matter and some would never experience the raptures of giving birth to an offspring. This is when egg donation comes into the picture. We at Buzzle, provide you some valuable information about this entire process.

What is Egg Donation?

Sometimes, a woman may donate one ovum or several ova either for the purpose of assisting in reproduction, of other women having infertility issues and other adverse reproductive conditions, or for the purpose of biomedical research. Most of the time, donated eggs are used for assisted reproduction. For this purpose, the eggs or ova undergo in vitro fertilization process, under which, they get fertilized in a laboratory environment. The donor of the ova may be anonymous (unrelated and unknown to the recipients), designated (known to the recipient, usually a relative or friend) or participants of shared oocyte programs.

The recipients of such third party ova usually consist of female individuals, whose reproductive conditions do not allow them to bear genetic offspring or who have crossed the fertile period of her life due to advanced reproductive age. Sometimes, birth defects affecting the reproductive system such as absolute or partial absence of certain reproductive organs may also prompt such women to seek donated eggs. Any damage or disorder of the reproductive organs, such as ovarian cysts and malignant growths, leading to their surgical removal, and other gynecological problems may also render a woman unable to conceive. Such women also benefit from third party reproduction programs.

The Procedure

There are a few steps that are involved in the entire procedure. After a donor is recruited, she is made to undergo a thorough medical screening to ascertain the soundness of her health and the health of her ova. The medical screening includes a pelvic examination, a test of her hormone levels, and a screening for infections and other diseases that might affect the health of her ova. An ultrasound screening is conducted to examine the reproductive organs of the donor to determine whether or not, there are any abnormalities or deformities in those organs. Next comes a psychological evaluation to ascertain, whether the donor is mentally prepared and emotionally equipped for donating her eggs. This is followed by the donor signing a legal contract with the laboratory. On signing the legal contract, the donor relinquishes any rights of custody and ownership over any child that results from any pregnancy, which may be induced by her donated ova.

Thereafter, IVF stimulation therapy is initiated. The donor is given birth control medications in order to synchronize her menstrual cycle with that of the recipient. This is followed by hormone regulating medication, which obstructs the normal ovarian functions of the donor. Thereafter, to stimulate the production of the ova and accelerate the rate of maturation of such ova, follicle stimulating hormones are administered to the donor. The entire process is supervised by medical experts to keep an eye on the growth and development of the donor's ova, and to monitor, how the donor reacts to the hormones that are administered as part of the donation process.

Next comes egg retrieval. Once the follicles have matured sufficiently, the doctor decides the date and time on which, the ova would be retrieved for fertilization. About 36 hours preceding retrieval, the donor receives one last shot of hCG hormone as a means of preparing her ova for harvesting. The process of retrieval requires a minimal surgically invasive procedure and takes somewhere around twenty-five to thirty minutes. After the extraction is over, the donor may be released within a couple of hours of resting period and observation, and she may resume her usual activities from the very next day.

How Long Does It Take

Once a donor is recruited and after she has undergone medical screening, psychological evaluation, and has signed the legal contract, the rest of the process - right from IVF stimulation to egg retrieval - takes somewhere between three to six weeks, depending upon the variations between the donor's and the recipient's reproductive cycles.

Egg donation is a noble cause and it is extremely encouraging to look at the motivational statistics, that point towards altruism as the sole motivation for the majority of women to act as donors. Only a small percentage quote monetary considerations as their motivation to donate eggs. The process of donation is not completely devoid of risks, though the incidences of such risks are negligible, given the thorough medical and psychological screening, that the donors are made to undergo. The risks may include adverse reaction to administered hormones, bleeding, and ovarian hyper stimulation syndrome. Some donors may even experience some psychological blocks on or after donation, however, this is quite rare. Certain studies have pointed towards possibilities of developing ovarian cancer, which may result from long-term, repetitive participation in egg donation programs. The recipients may also be vulnerable to transmittable diseases and infections, however, given the intensive donor screenings, such an occurrence is extremely rare.

Wednesday, October 29, 2014

Embryonic Stem Cell Research

What are Stem Cells?
Stem cells can be described as the repair kits of our body. They are unspecialized cells that are found in the bodies of all multi-cellular creatures, that have the potential to develop into specialized cells.

Where are Embryonic Stem Cells found?
Embryonic stem cells are found in blastocysts. When a fertilized egg has undergone cell division for 5 days, it forms a hollow ball of cells. This developing embryo is known as a blastocyst. The embryonic stem cells are derived from this. It should be noted that only an egg that has been fertilized through the In Vitro Fertilization process is used.

What are the properties of Embryonic Stem Cells?
Embryonic stem cells possess remarkable properties of limitless self-renewal through cell-division, and can develop into new stem cells or more specialized types of body cells. The process of self-replication is called proliferation, and when the unspecialized cells undergo cell division, and bring forth specialized cells it is called differentiation.

Embryonic Stem Cell Research
How are Embryonic Stem Cells cultivated?
The blastocyst has three main parts - the trophoblast, the blastocoel, and the inner cellular mass. Embryonic stem cells are derived from this inner cellular mass, which are cultivated in a culture medium in a laboratory, over a period of time. These cells divide and proliferate, forming millions of new embryonic cells. These embryonic stem cells can remain undifferentiated or, under certain conditions, can begin to differentiate and produce specialized cells like nerve cells, blood cells, etc.

What are the uses of Embryonic Stem Cells?
Since embryonic stem cells have the potential to develop into a variety of specialized cells, they are very important in medical research. Scientists involved in embryonic stem cell research are trying to understand the conditions under which specific specialized cells are produced. By knowing how to bring about or control these conditions, they can then produce the required specialized cells on demand. These specialized cells can possibly be used in regenerative treatments for spinal cord injuries or to cure diseases like Alzheimer's disease, Parkinson's disease, diabetes, cancer, heart diseases, etc.

What are the moral and ethical issues involved in Embryonic Stem Cell usage?
As mentioned before, the embryos used in embryonic stem cell research are developed from eggs, that have been fertilized by the In Vitro Fertilization process. The eggs used are the ones that have been willingly donated for research purposes and which, as per the agreement with the donor, are never to be transplanted into a uterus to develop into a human being.

After the embryonic stem cells are extracted, there is no further development of the blastocyst. This poses as a moral problem to many religious organizations. Is it okay to let an embryo - a developing life - die in order to potentially cure diseases and alleviate suffering in those already living? However, is it right to snatch the very possibility of cure, from the hands of those suffering from fatal diseases? 

Pro-life groups feel that the end does not justify the means. In other words, a blastocyst - a hollow ball of cells that is not technically a person – should not be sacrificed for the sake of research. Life is too precious.

source by : http://www.buzzle.com/articles/stem-cell-research/

Cord Blood Banking Pros and Cons

Umbilical cord blood storage is a relatively new procedure in medical science, which promises to protect a baby from life-threatening illnesses in the future. Though it has been purported to be an ultimate source for transplant therapy in childhood cancer patients, a lot of queries about cord blood storage linger in the mind of expecting parents.

What is Umbilical Cord Blood Banking?

The umbilical cord blood is nearly similar to regular blood that is continuously circulated in our body. In short, it has all the three components that blood has, viz. Red Blood Cells (RBCs), White Blood Cells (WBCs), and plasma (blood medium). What is so unique about cord blood is the presence of stem cells that have the ability to develop into other types of cells. In the procedure for cord blood banking, blood from the umbilical cord is collected immediately after childbirth. It is then processed to remove unwanted particles, and stored under cryogenic conditions.

Cord Blood Banking

Both public and private blood banks provide facilities for preserving cord blood. For storing in public centers, the mother needs to go through a general health examination, and pass the criteria set by the organization. Those maintained in public centers are normally used for stem cell research, while some parents opt for storing cord blood in a private blood bank by paying the necessary charges. Before making a decision for this, understand the various related pros and cons.



Pros
With cord blood banking, the stored blood can be used as a source for extracting stem cells, when the child, his/her sibling, or any immediate family member is diagnosed with severe disease that can be treated by transplant therapy. If parents can afford, cord blood banking privately is no less than a lifelong insurance for newborns, who have a familial history of genetic disorders, blood cancer, thalassemia, and similar illnesses. Using one's own cells reduces the risks for graft-versus-host medical complications.

So is the procedure worth the cost? The American Academy of Pediatrics (AAP) supports the procedure of umbilical cord blood banking for families who can afford it. Not only for the child for whom cord blood is stored, the stem cells can be used for compatible siblings and relatives as well. It is estimated that every child has one in 1,000 to one in 200,000 chances of using umbilical cord blood in his/her later life. Thus, storing cord blood is a wise step towards ensuring a safe future.

Cons
The high price is a major concern for everyone interested. A trustful private blood bank may charge approximately USD 2,000 - 2,200 for the enrollment process. In addition to this collection fee, cord blood banking cost includes a yearly fee for maintenance, which comes to about USD 100. Thus, umbilical cord blood storage may not be affordable for every parent, even if it sounds logical for insuring their child.

Another problem is the need for proper planning. It does happen in families that the decision for banking cord blood is taken too late to be put into action. Ideally, one should contact a private cord blood bank when the pregnancy term is 34 weeks. This is because the collected blood requires an individual kit and special arrangements for storage. Besides this, the collected cord blood is a limited sample (about 3 - 5 ounces only). Hence, it may not be sufficient for use in stem cell transplants for adults.

Considering the high cost, this might be a hard decision to make. On the brighter side, chances of getting matching donors are high, as there are several public banks with facilities for cord blood storage.

source by : http://www.buzzle.com/articles/cord-blood-banking-pros-and-cons.html